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Activated via the antibiotic rifampicin and various plant metabolites, for instance hyperforin, guggulipid, colupulone, and isoflavones. Reaction to unique ligands is species-particular. Activated by In a natural way happening steroids, including pregnenolone and progesterone. Binds to a response component in the promoters with the CYP3A4 and ABCB1